The new white blood cells migrate into the blood and fight the infection. Direct proliferative actions of stem cell factor on murine bone marrow cells in vitro. Pdf the structure of granulocytecolony stimulating factor gcsf. Granulocyte colonystimulating factor attenuates neuronal death. Colony stimulating factors csfs prior approval criteria. Patient risk factors for the development of febrile neutropenia include but are not limited to nccn guidelines version 1. In this context, their receptors were unexpectedly found on painsensing nerves and were observed to be functionally linked to nociceptive. Colony stimulating factors tend to reduce the time where patients are neutropenic. Paralogs of common carp granulocyte colonystimulating factor. The four factors are interleukin3 il3, stem cell factor scf or kit ligand, granulocyte colony stimulating factor gcsf, and granulocytemacrophage colony stimulating factor gmcsf. Colony stimulating factors csfs prior approval criteria august 2017 overview colony stimulating factors csfs are biosynthetic products that stimulate the development of white blood cells such as neutrophils and macrophages infectionfighting blood cells. Hematopoietic properties of granulocyte colonystimulating factor. Mammalian granulocyte colonystimulating factor gcsf. Granulocyte colonystimulating factor gcsf is a protein that stimulates.
Colony stimulating factors are used in patients who are undergoing cancer treatment that causes low white blood cell counts neutropenia and puts the patient at risk of infections. Fax signed forms to aetna better health of michigan at 18557992551. Overall, gcsf did not improve stroke outcome in this individual patient data metaanalysis. These include growth factors, cytokines and peptides, which have the. These factors are released from activated tlymphocytes, monocytes, and endothelial cells at the site of infection to stimulate granulopoiesis. Pdf we have determined the threedimensional structure of recombinant human granulocytecolonystimulating factor by xray crystallography. Please contact aetna better health of michigan at 18663163784 with questions regarding the prior authorization process. Colony stimulating factors this fax machine is located in a secure location as required by hipaa regulations. Previously we showed that granulocyte colonystimulating factor. It regulates the production, maturation, andfunction of the neutrophil lineage.
Colony stimulating factor an overview sciencedirect topics. Granulocytecolony stimulating factor gcsf for stroke. To determine whether selective responses to colony stimulating factors of normal versus abnormal clones occurred, cytogenetic analysis was performed on. Effects of combination with colonystimulating factors. Poor performance status eastern cooperative oncology group 3 or 4 or hiv infection in particular, those with low cd4 counts. Colonystimulating factors csfs are secreted glycoproteins that bind to receptor proteins on the surfaces of hemopoietic stem cells, thereby activating intracellular signaling pathways that can cause the cells to proliferate and differentiate into a specific kind of blood cell usually white blood cells. Is the request for an inpatient that is awaiting discharge. Administration of exogenous colony stimulating factors stimulates the stem cells in the bone marrow to produce more of the particular white blood cells.